PROFIL PRACOWNIKA: Barbara Ziemba

I am an experienced biologist with a background in various research centers. My expertise includes working with cell cultures, laboratory animals, molecular techniques, data analysis, and preparing detailed reports. I am enthusiastic and eager to gain new experiences and further develop my skills.

EDUCATION AND SCIENTIFIC WORK

05.2024 - present Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Łódź

ASSISTANT PROFESSOR

11/2016 - 04/2024 Department of Clinical Genetics, Medical University of Lodz

SENIOR SCIENTIFIC AND TECHNICAL SPECIALIST

Planning and implementing four scientific projects as a manager or main contractor (use of dendrimers and dendriplexes in cancer).

09/2012 - 09/2015 Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Łódź

ASSISTANT PROFESSOR

Implement two scientific projects as a contractor: research on the impact of dendrimers on cancer cells and the effect of photobiomodulation on mesenchymal stem cells.

11/2008 - 06/2012 PhD studies in Biochemistry and Biophysics, Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Łódź

DOCTOR OF BIOLOGICAL SCIENCES, BIOPHYSICS

"Toxicity of polypropyleneimine dendrimers"

02/2007 - 10/2008 Research Laboratory for Medicine and Veterinary Products in the GMP Quality System, Nofer Institute of Occupational Medicine in Łódź

TECHNICAL ASSISTANT

Toxicity and pyrogenicity testing of medical devices using laboratory animals.

10/2001 - 06/2006 Uniform Master's degree studies, Faculty of Biology and Environmental Protection, University of Łódź

MASTER in BIOLOGY, SPECIALIZATION in BIOCHEMISTRY

"DNA damage and repair in Helicobacter pylori infection"

Research stays at home and abroad

04-05.2011
Laboratorio Inmuo-Biología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Scientific research: Influence of poly(propylene imine) dendrimers on cancer cells.

• Toxicity and proapoptotic activity of poly(propylene imine) glycodendrimers in vitro: considering their contrary potential as biocompatible entity and drug molecule in cancer. Ziemba B, Franiak-Pietryga I, Pion M, Appelhans D, Muñoz-Fernández MÁ, Voit B, Bryszewska M, KlajnertMaculewicz B. Int J Pharm. 2014 Jan 30;461(1-2):391-402. doi: 10.1016/j.ijpharm.2013.12.011.

07.2011
Institute of Biophysics and Cellular Engineering of Belarusian National Academy of Sciences, Minsk, Belarus
Scientific research: Influence of poly(propylene imine) dendrimers on blood platelets.

• Influence of fourth generation poly(propyleneimine) dendrimers on blood cells. Ziemba B, Halets I, Shcharbin D, Appelhans D, Voit B, Pieszynski I, Bryszewska M, Klajnert B. J Biomed Mater Res A. 2012 Nov;100(11):2870-80. doi: 10.1002/jbm.a.34222.

11.2011-03.2013
Laboratory of Clinical and Transplant Immunology and Genetics, Copernicus Memorial Hospital in Lodz, Poland
Scientific research: Influence of poly(propylene imine) glycodendrimers on chronic lymphocytic leukemia cells.

• The influence of maltotriose-modified poly(propylene imine) dendrimers on the chronic lymphocytic leukemia cells in vitro: dense shell G4 PPI. Franiak-Pietryga I, Ziółkowska E, Ziemba B, Appelhans D, Voit B, Szewczyk M, Góra-Tybor J, Robak T, Klajnert B, Bryszewska M. Mol Pharm. 2013 Jun 3;10(6):2490-501. doi: 10.1021/mp400142p.

My scientific interests are related to the nanoparticles as drugs or as drug carriers in cancer diseases.

Prizes and awards

• Winner of the 'Innovations in Medicine' competition at Forge of Talents 2020. Team Award;
  MediHUB; Medical University of Lodz (2020)

• Rector's Awards for a series of publications on the use of dendrimers as a form of modern treatment in patients with chronic lymphocytic leukaemia. Team Award;
  Medical University of Lodz (2017)

• Rector's Awards for a series of publications related to the PhD thesis: 'Toxicity of poly(propylene imine) dendrimers';
  University of Lodz (2013)

• Salary award in 'Scholarships supporting innovative research by PhD students' project;
  European Social Fund (Brussels, BE) (2009)

• PhD scholarship in 'Biological properties and biomedical applications of dendrimers' project;
  Foundation for Polish Science; TEAM/2008-1/5; University of Lodz (2008-2012)

• Academic Achievement Scholarship;
  University of Lodz (2005-2006)

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Patent pending P.448724

'Dendriplex composed of PPI dendrimer and RNA, a pharmaceutical composition containing such a dendriplex and such a composition for use as a medicine and for use in cancer therapy'.

Polish Patent Office
05.2024

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List of scientific projects:

• PPI dendrimers as siRNA carriers in gene therapy against rhabdomyosarcoma (ARMS); NCN Miniatura 2; Head of scientific activity; 04/2019 - 06/2020
• Gene therapy of alveolar rhabdomyosarcoma (ARMS) using PPI-G4 glycodendrimer as a nucleic acid carrier; Innovation Incubator 4.0 (POIR 2014-2020); Contractor of pre-implementation works; Manager: Ida Franiak-Pietryga; 01/2021-12/2022
• Determination of the maximum tolerated dose (MTD) for nanoparticles (glycodendrimers) with potential use in B-cell lymphoproliferative diseases in a laboratory rat model; EIT Health (Horizon 2020) and NCBR 'BRIdge Alfa'; The Contractor; Manager: Ida Franiak-Pietryga; 11/2016-09/2017
• Assessment of the effectiveness of nanoparticles (glycodendrimers) with potential application in B-cell lymphoproliferative diseases using a xenotransplantation model in mice; (EIT Health) Horizon 2020 and NCBR 'BRIdge Alfa'; The Contractor; Manager: Ida Franiak-Pietryga; 11/2016-09/2017
• The influence of biostimulating laser radiation on mesenchymal stem cells; Internal project of the Medical University of Lodz; Co-contractor; Manager: Kamila Pasternak Mnich; 11/2014-06/2015
• Dendrimers - potential drugs in chronic lymphocytic leukemia; NCN OPUS; The Contractor; Manager: Maria Bryszewska; 09/2012-11/2014
• Biological properties and biomedical applications of dendrimers; FNP TEAM/2008-1/5; Scholarship holder; Manager: Barbara Klajnert-Maculewicz; 11/2008-08/2012